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PJ Hansen Animal Sciences AMCB IFAS College of Vet Med University of Florida

ANS 6313 - Current Concepts in Reproductive Biology

Readings

8/23 |  9/1  |  9/6 | 9/18 | 9/20 | 9/25 | 10/2 | 10/9

 10/16 | 10/23 | 10/30 | 11/6 | 11/13 | 11/20 | 11/27

 

August 23

 

Organizational Meeting

 

Sept 1- No Class

 

Sept 6 -  Regulation of LH Secretion (Barbara Loureiro)

 

Ferris HA, Shupnik MA. Mechanisms for pulsatile regulation of the gonadotropin subunit genes by GNRH1. Biol Reprod 2006;74:993-8.

 

Bilezikjian LM, Blount AL, Donaldson CJ, Vale WW. Pituitary actions of ligands of the TGF-beta family: activins and inhibins. Reproduction 2006;132:207-15.

 

Original research paper

Garrido-Gracia JC, Gordon A, Bellido C, Aguilar R, Barranco I, Millán Y, de Las
Mulas JM, Sánchez-Criado JE. The integrated action of oestrogen receptor isoforms and sites with progesterone receptor in the gonadotrope modulates LH secretion: evidence from tamoxifen-treated ovariectomized rats. J Endocrinol 2007;193:107-19.

 

Sept 18 (Tuesday)  - Circadian Rhythms and Reproduction (Luciano Silva)

 

Boden MJ, Kennaway DJ. Circadian rhythms and reproduction.

Reproduction 2006;132:379-92.

 

de la Iglesia HO, Schwartz WJ. Minireview: timely ovulation: circadian regulation of the female hypothalamo-pituitary-gonadal axis. Endocrinology 2006;147:1148-53.

 

Original research paper

Lincoln GA, Clarke IJ, Hut RA, Hazlerigg DG. Characterizing a mammalian circannual pacemaker. Science 2006;314:1941-4.
 

Sept 20 – Hormonal Links between Nutrition and Reproduction (Flavia Cooke)

 

Blache D, Zhang S, Martin GB. Dynamic and integrative aspects of the regulation of reproduction by metabolic status in male sheep. Reprod Nutr Dev 2006;46:379-90.

 

Garcia MC, Lopez M, Alvarez CV, Casanueva F, Tena-Sempere M, Dieguez C. Role of ghrelin in reproduction. Reproduction 2007;133:531-40.

 

Acosta-Martinez M, Horton T, Levine JE. Estrogen receptors in neuropeptide Y neurons: at the crossroads of feeding and reproduction.  Trends Endocrinol Metab 2007;18:48-50.

 

Original research paper

Martini AC, Fernández-Fernández R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 2006;147:2374-82.

 

Sept 25 – Estrogen Signaling (Kathleen Pennington)

 

Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, Tujague M, Ström A, Treuter E, Warner M, Gustafsson JĹ. Estrogen receptors: how do they signal and what are their targets. Physiol Rev 2007;87:905-31.

 

Song RX, Santen RJ. Membrane initiated estrogen signaling in breast cancer. Biol Reprod 2006;75:9-16.

 

Original research paper

Cherlet T, Murphy LC. Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors. Mol Cell Biochem, in press.

 

Oct 2 – Hormonal and Local Regulators of Endometrial Function (Qien Yang)

 

Groothuis PG, Dassen HH, Romano A, Punyadeera C.  Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human. Hum Reprod Update 2007;13:405-17.

Hannan NJ, Salamonsen LA. Role of chemokines in the endometrium and in embryo implantation.  Curr. Opin. Obstet. Gynecol 2007;19:266-72.

 

Original research paper

Kaitu'u-Lino TJ, Morison NB, Salamonsen LA. Estrogen Is not essential for full endometrial restoration after breakdown: lessons from a mouse model. Endocrinology. 2007;148:5105-5111.

 

Oct 9 – Germ Cell Interactions with the Gonad (Claudia Klein)

 

Guigon CJ, Magre S. Contribution of germ cells to the differentiation and maturation of the ovary: insights from models of germ cell depletion. Biol Reprod 2006; 74:450-8.  To get color, go to the html version at http://www.biolreprod.org/cgi/content/full/74/3/450.

 

Liu K, Rajareddy S, Liu L, Jagarlamudi K, Boman K, Selstam G, Reddy P. Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. Dev Biol 2006;299:1-11.

 

Kimble J, Page DC. The mysteries of sexual identity. The germ cell's perspective. Science 2007;316:400-1.

 

Original research paper

Guéripel X, Brun V, Gougeon A. Oocyte bone morphogenetic protein 15, but not growth differentiation factor 9, is increased during gonadotropin-induced follicular development in the immature mouse and is associated with cumulus oophorus expansion. Biol Reprod 2006;75:836-43.

 

Oct 16 – Unique Structures Associated with Spermatogenesis (Aline Bonilla)

 

Yan HH, Mruk DD, Lee WM, Cheng CY.  Ectoplasmic specialization: a friend or a foe of spermatogenesis? Bioessays 2007;29:36-48.

 

Kotaja N, Sassone-Corsi P.  The chromatoid body: a germ-cell-specific RNA-processing centre. Nat Rev Mol Cell Biol 2007;8:85-90.

 

Original research paper

Kotaja N, Lin H, Parvinen M, Sassone-Corsi P. Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci 2006 119:2819-25.

 

Oct 23 – Oocyte Maturation (Kun Zhang)

 

Gilchrist RB, Thompson JG. Oocyte maturation: emerging concepts and technologies to improve developmental potential in vitro. Theriogenology 2007 67:6-15.

 

Brevini TA, Cillo F, Antonini S, Gandolfi F. Cytoplasmic remodelling and the acquisition of developmental competence in pig oocytes. Anim Reprod Sci 2007 98:23-38.

 

Original research paper

Hussein TS, Thompson JG, Gilchrist RB. Oocyte-secreted factors enhance oocyte developmental competence. Dev Biol. 2006;296:514-21

 

Oct 30 – Developmental Control of Gene Expression in Embryos (Justin Fear)

 

Brevini TA, Cillo F, Antonini S, Tosetti V, Gandolfi F. Temporal and spatial control of gene expression in early embryos of farm animals. Reprod Fertil Dev 2007;19:35-42.

 

Schier AF. The maternal-zygotic transition: death and birth of RNAs. Science. 2007;316:406-7.

 

Stitzel ML, Seydoux G. Regulation of the oocyte-to-zygote transition. Science 2007;316:407-8.

 

Original research paper

Ferg M, Sanges R, Gehrig J, Kiss J, Bauer M, Lovas A, Szabo M, Yang L, Straehle U, 

Pankratz MJ, Olasz F, Stupka E, Müller F. The TATA-binding protein regulates maternal 

mRNA degradation and differential zygotic transcription in zebrafish.

EMBO J 2007;26:3945-56.

 

Nov 6 – Differentiation of the Preimplantation Embryo (Izabella Thompson)

 

Yamanaka Y, Ralston A, Stephenson RO, Rossant J.  Cell and molecular regulation of the mouse blastocyst. Dev Dyn 2006;235:2301-14.

 

Selwood L, Johnson MH.  Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins. Bioessays 2006 28:128-45.

 

Original research paper

Tolkunova E, Cavaleri F, Eckardt S, Reinbold R, Christenson LK, Schöler HR, Tomilin A. The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells. Stem Cells 2006;24:139-44.

 

Nov 13 – The Ruminant as a Model for Maternal-Conceptus Interactions (Kiri Dunn)

 

Spencer TE, Johnson GA, Bazer FW, Burghardt RC, Palmarini M. Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses. Reprod Fertil Dev 2007;19:65-78.

Hashizume K. Analysis of uteroplacental-specific molecules and their functions during implantation and placentation in the bovine. J Reprod Dev 2007;53:1-11

Original research paper

Arnold DR, Bordignon V, Lefebvre R, Murphy BD, Smith LC. Somatic cell nuclear transfer

alters peri-implantation trophoblast differentiation in bovine embryos.

Reproduction 2006;132:279-90.

 

Nov 20 - Thanksgiving – No Class

 

Nov 27 - Fetal-Maternal Conflict, Imprinting and Evolution of the Placenta (Scott Bailey)

 

Smith FM, Garfield AS, Ward A.  Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res 2006; 113:279-91.

 

Mess A, Carter AM.  Evolution of the placenta during the early radiation of placental mammals. Comp Biochem Physiol A Mol Integr Physiol 2007, in press.

 

Original research paper
Ager E, Suzuki S, Pask A, Shaw G, Ishino F, Renfree MB. Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Dev Biol. 2007;309:317-28.