An efficient system to treat ovarian follicular cysts in cattle has been developed. In this system, a GnRH agonist is injected to luteinize the cyst and induce recruitment and selection of a new follicle. At the time of GnRH agonist treatment, an intravaginal progesterone device is inserted to reduce the endogenous pulsatility of LH. On day 7 after insertion of the intravaginal progesterone device, an injection of PGF_2α is given to regress any induced CL formed from an active subordinate follicle present at the time of GnRH agonist treatment. The intravaginal progesterone device is removed on day 9 after insertion and cows express estrus on day 11. Associated with the induced estrus is a normal ovulation and subsequent CL development with re-occurring follicular waves throughout the estrous cycle. Thus successful treatment is completed within a 11 day period.